Structural & Functional Processing & DerivativesπŸ”—

For structural and functional MRI processing, file selection is based on raw data quality control metrics, including:

  • Overall passing QC score (QC = 1)
  • Motion score below a defined threshold (QU_Motion ≀ 2 for the current release)
  • If multiple scans are present for a given modality (T1w/T2w), the scan with the highest QC metrics is used

All processing streams utilized both the T1w and T2w if they were present. Processing was still executed with only a single modality present as well, with certain requirements depending on the surface reconstruction method utilized within Infant fMRIPrep (see details):

  • M-CRIB-S (T2w-based): requires T2w
  • Infant FreeSurfer (T1w-based): requires both T1w and T2w

Multistep Processing WorkflowπŸ”—

HBCD structural and functional MRI data are processed through a sequence of BIDS App pipelines. At a high level, BIBSNet generates brain tissue segmentations and masks for T1w/T2w images. These are fed into Infant-fMRIPrep to generate confound files and motion-corrected data (in MNI space, registered to age-specific volumetric atlases) as well as fs_LR32k surface space. Outputs are then fed into XCP-D to run nuisance regression/denoising, parcellate the fMRI data, and compute summary measures.


BIBSNetπŸ”—

BIBSNet is a deep learning model optimized for infant MRI brain tissue segmentation (Hendrickson et al. 2024). The BIBSNet pipeline generates native-space brain segmentations and brain masks (as well as volumes.tsv files with ROI volume statistics), which are fed into Infant fMRIPrep for use in anatomical preprocessing and surface reconstruction.

hbcd/
└── derivatives/ 
    └── bibsnet/
        └── sub-[ID]/
            └── ses-[V0X]/
                └── anat/
                    β”œβ”€β”€ sub-[ID]_ses-[V0X]_space-{T1w|T2w}_desc-aseg_dseg.nii.gz (+JSON)
                    β”œβ”€β”€ sub-[ID]_ses-[V0X]_space-{T1w|T2w}_desc-aseg_volumes.tsv (+JSON)         
                    └── sub-[ID]_ses-[V0X]_space-{T1w|T2w}_desc-aseg_brain-mask.nii.gz (+JSON)

 How To Read File Trees β†’

Infant fMRIPrepπŸ”—

Infant-fMRIPrep (also known as NiBabies) performs minimal structural and functional MRI processing. It is an adapted version of fMRIPrep optimized for infant data processing, using age-appropriate templates and surface reconstruction methods optimized for early development (Goncalves et al., 2025). Pipeline outputs include visual quality assessment reports, preprocessed derivatives, and confounds used for denoising in subsequent processing steps.

Anatomical Preprocessing
T1w and T2w images are denoised, bias-corrected, and normalized to the MNI Infant template (0–4.5 yr), then to MNI152 for compatibility with adult datasets. Surface reconstruction is performed via one of the following methods:

M-CRIB-S T2w-based method for neonates (Adamson et al., 2020). Infant fMRIPrep runs a modified MCRIBReconAll workflow that uses the BIBSNet-derived brain segmentation. Optimal age range per Goncalves et al., 2025: ≀ 5 months
Infant FreeSurfer T1w-based method for infants 0-2 years old (ZΓΆllei et al., 2020). Infant fMRIPrep executes infant_recon_all with its default configuration. Optimal age range per Goncalves et al., 2025: β‰₯ 3 months

Functional Processing

  • Motion and distortion correction using fieldmap-based estimation.
  • Alignment of functional to anatomical space via boundary-based registration.
  • Confound estimation: framewise displacement (FD) and DVARS for motion, CompCor physiological noise regressors, global signals (mean CSF, white matter, and whole brain), and derived regressors (e.g. motion outlier flags for frames exceeding 0.5 mm FD or 1.5 standardized DVARS thresholds)
  • Resampling of BOLD data to subject and fsLR-space surfaces, with grayordinates (91k) for surface-based analyses.

Overview

  • JSON files excluded for brevity from file trees below
  • See How To Read File Trees for additional guidance
  • T1w-related files will only be present in the derivatives if a T1w was acquired
hbcd/
└── derivatives/
    └── nibabies-{HASH}/
        └── sub-[ID]/
            β”œβ”€β”€ figures/
            β”œβ”€β”€ ses-[V0X]/
            β”‚   β”œβ”€β”€ anat/
            β”‚   β”œβ”€β”€ fmap/
            β”‚   β”œβ”€β”€ func/
            β”‚   └── log/
            β”‚
            └── sub-[ID]_ses-[V0X]_hash-{HASH}.html

# Label Values Legend
HASH: 0f306a2f , 2afa9081

Anatomical Folder Details

...
└── ses-[V0X]/
    └── anat/
        # Primary volumetric outputs & segmentations
        β”œβ”€β”€ *_desc-preproc_{T1w|T2w}.nii.gz
        β”œβ”€β”€ *_space-MNI152NLin6Asym_res-2_desc-preproc_T2w.nii.gz
        β”œβ”€β”€ *_space-MNI152NLin6Asym_res-2_desc-brain_mask.nii.gz
        β”œβ”€β”€ *_space-T2w_desc-ribbon_mask.nii.gz
        β”œβ”€β”€ *_space-{STD_SPACE}_dseg.nii.gz
        β”œβ”€β”€ *_space-T2w_desc-{aparcaseg|aseg}_dseg.nii.gz
        β”œβ”€β”€ *_space-{STD_SPACE}_label-{CSF|GM|WM}_probseg.nii.gz

        # Transforms
        β”œβ”€β”€ *_from-{SPACE}_to-T2w_mode-image_xfm.h5
        β”œβ”€β”€ *_from-T2w_to-{SPACE}_mode-image_xfm.h5

        # Surface & CIFTI outputs
        β”œβ”€β”€ *_hemi-{L|R}_desc-cortex_mask.label.gii
        β”œβ”€β”€ *_space-fsLR_den-91k_{METRIC}.dscalar.nii 
        β”œβ”€β”€ *_hemi-{L|R}_{METRIC}.shape.gii
        β”œβ”€β”€ *_hemi-{L|R}_{inflated|sphere}.surf.gii
        β”œβ”€β”€ *_hemi-{L|R}_{SURF}.surf.gii
        β”œβ”€β”€ *_hemi-{L|R}_space-dhcpAsym_den-32k_{SURF}.surf.gii
        └── *_hemi-{L|R}_space-{dhcpAsym|fsaverage}_reg_sphere.surf.gii   
...
# Label Values Legend
File Prefixes (anat/, fmap/ files): sub-[ID]_ses-[V0X]_hash-{HASH}_run-[X]
METRIC: curv , sulc , thickness 
SPACE: fsnative , MNI152NLin6Asym , MNIInfant+1 , T1w
STD_SPACE: MNI152NLin6Asym_res-2 , T2w
SURF: midthickness , pial , white  

Fieldmap & Functional Folder Details

... 
└── ses-[V0X]/
    β”œβ”€β”€ fmap/
    β”‚   └── *_fmapid-auto[X]_desc-{coeff|epi|preproc}_fieldmap.nii.gz
    β”‚
    └── func/
        # BOLD & masks
        β”œβ”€β”€ *_desc-{preproc_bold|brain_mask}.nii.gz
        β”œβ”€β”€ *_space-{STD_SPACE}_boldref.nii.gz
        β”œβ”€β”€ *_space-{STD_SPACE}_desc-{preproc_bold|brain_mask}.nii.gz

        # Motion-corrected or coregistered outputs
        β”œβ”€β”€ *_desc-{hmc|coreg}_boldref.nii.gz
        β”œβ”€β”€ *_from-orig_to-boldref_mode-image_desc-hmc_xfm.txt
        β”œβ”€β”€ *_from-boldref_to-T2w_mode-image_desc-coreg_xfm.txt
        β”œβ”€β”€ *_from-boldref_to-auto*_mode-image_xfm.txt

        # Surface & CIFTI outputs
        β”œβ”€β”€ *_space-fsLR_den-91k_bold.dtseries.nii
        β”œβ”€β”€ *_hemi-{L|R}_space-fsnative_bold.func.gii 

        # Confounds
        └── *_desc-confounds_timeseries.tsv 

# Label Values Legend
File Prefixes (func/): sub-[ID]_ses-[V0X]_hash-{HASH}_task-rest_dir-PA_run-[X]
STD_SPACE: MNI152NLin6Asym_res-2 , T2w

M-CRIB-S & FreeSurferπŸ”—

Infant fMRIPrep and XCP-D derivative folder/filenames include unique hash IDs to indicate distinct processing parameters used for a given pipeline. In the case of HBCD data, the hash IDs correspond to which surface reconstruction method was used for processing within Infant fMRIPrep.

M-CRIB-S & FreeSurfer are alternative surface reconstruction methods supported by Infant fMRIPrep, optimized for different age ranges (see details above).

Method Hash ID Description Visits (Age Range in Months)
M-CRIB-S 0f306a2f T2w-based method for neonates V02 (0-1 m)
Infant FreeSurfer 2afa9081 T1w-based method for infants 0-2 years old V02 (0-1 m), V03 (3-9 m), V04 (9-15 m)

Downstream XCP-D derivatives include a second hash ID (0ef9c88a) indicating the XCP-D processing configuration. This value is identical for all HBCD data because the XCP-D parameters were fixed. Below we summarize the processing workflows and resulting derivative folder names.

Detailed MRI Processing Workflow

The M-CRIB-S and FreeSurfer derivative folders are generated from the intermediate FreeSurfer-like folders produced by Infant fMRIPrep during surface reconstruction. When M-CRIB-S is used, Infant fMRIPrep still creates a FreeSurfer-structured folder containing the M-CRIB-S results mapped to the standard recon-all layout; these appear in the release under freesurfer-0f306a2f/.

hbcd/
└── derivatives/
    └── freesurfer-{HASH}/
        └── sub-[ID]_ses-[V0X]/
            β”œβ”€β”€ label/
            β”‚   β”œβ”€β”€ {lh|rh}.{ATLAS}.annot
            β”‚   β”œβ”€β”€ {lh|rh}.{ATLAS}.auto.nomask.annot
            β”‚   └── {lh|rh}.cortex.label
            β”‚
            β”œβ”€β”€ mri/
            β”‚   β”œβ”€β”€ T2.mgz
            β”‚   β”œβ”€β”€ {ATLAS}+aseg.mgz
            β”‚   β”œβ”€β”€ aseg*.mgz
            β”‚   β”œβ”€β”€ {brain|brainmask}.mgz
            β”‚   β”œβ”€β”€ {lh|rh}.ribbon.mgz
            β”‚   β”œβ”€β”€ norm.mgz
            β”‚   β”œβ”€β”€ orig.mgz
            β”‚   └── ribbon.mgz
            β”‚
            β”œβ”€β”€ stats/
            β”‚   β”œβ”€β”€ aseg.stats
            β”‚   β”œβ”€β”€ brainvol.stats
            β”‚   β”œβ”€β”€ {lh|rh}.{ATLAS}.stats
            β”‚   └── {lh|rh}.curv.stats
            β”‚
            β”œβ”€β”€ surf/
            β”‚   β”œβ”€β”€ {lh|rh}.{white,pial,midthickness}
            β”‚   β”œβ”€β”€ {lh|rh}.{inflated,sphere}*
            β”‚   β”œβ”€β”€ {lh|rh}.smoothwm*
            β”‚   β”œβ”€β”€ {lh|rh}.{area,area.mid,area.pial}
            β”‚   └── {lh|rh}.{curv,sulc,thickness,volume}
            β”‚
            └── scripts/*

# Label Legend
HASH: 0f306a2f | 2afa9081
HEM: lh | rh
ATLAS: aparc | aparc+DKTatlas
hbcd/
└── derivatives/
    └── mcribs-0f306a2f/
        └── sub-[ID]_ses-V02/
            β”œβ”€β”€ RawT2/sub-[ID]_ses-V02.nii.gz
            β”œβ”€β”€ RawT2RadiologicalIsotropic/sub-[ID]_ses-V02.nii.gz_symlink_s3_object
            β”œβ”€β”€ SurfReconDeformable/
            β”‚   └── sub-[ID]_ses-V02/
            β”‚       β”œβ”€β”€ meshes/
            β”‚       β”‚   β”œβ”€β”€ {internal|pial|white|pial+internal|white+internal}.vtp
            β”‚       β”‚   β”œβ”€β”€ pial-{lh|rh}.vtp
            β”‚       β”‚   β”œβ”€β”€ pial-{lh|rh}-reordered.vtp
            β”‚       β”‚   └── white-{lh|rh}.{CortexMask.curv|Normals.surf|RegionId.curv|vtp}
            β”‚       β”œβ”€β”€ recon/
            β”‚       β”‚   β”œβ”€β”€ cortical-hull-dmap.nii.gz
            β”‚       β”‚   └── regions.nii.gz
            β”‚       └── temp/
            β”‚           β”œβ”€β”€ brain-mask.nii.gz
            β”‚           β”œβ”€β”€ ventricles-dmap.nii.gz
            β”‚           β”œβ”€β”€ t2w-image.nii.gz_symlink_s3_object
            β”‚           β”œβ”€β”€ cerebrum-{lh|rh}-dmap.nii.gz
            β”‚           β”œβ”€β”€ cerebrum-{lh|rh}-hull-[X].vtp
            β”‚           β”œβ”€β”€ cerebrum-{lh|rh}-iso.vtp
            β”‚           β”œβ”€β”€ {STRUCT}-mask-[X].nii.gz
            β”‚           β”œβ”€β”€ {cerebrum-lh|cerebrum-rh|pial|white}-[X].vtp
            β”‚           β”œβ”€β”€ {cerebrum-lh|cerebrum-rh|pial|white}-[X]-output_[X].vtp
            β”‚           β”‚
            β”‚           └── {pial|white}-foreground.nii.gz
            β”œβ”€β”€ TissueSeg/
            β”‚   β”œβ”€β”€ sub-[ID]_ses-V02_all_labels.nii.gz
            β”‚   β”œβ”€β”€ sub-[ID]_ses-V02_all_labels_manedit.nii.gz_symlink_s3_object
            β”‚   β”œβ”€β”€ sub-[ID]_ses-V02_brain_mask.nii.gz
            β”‚   └── sub-[ID]_ses-V02_t2w_restore.nii.gz_symlink_s3_object
            β”œβ”€β”€ TissueSegDrawEM/sub-[ID]_ses-V02/N4/sub-[ID]_ses-V02.nii.gz_symlink_s3_object
            β”œβ”€β”€ freesurfer/ # M-CRIB-S–specific outputs
            β”‚   └── sub-[ID]_ses-V02/
            β”‚       └── mri/
            β”‚           └── {brain|orig}.mgz_symlink_s3_object
            β”œβ”€β”€ logs/sub-[ID]_ses-V02.log
            └── command.txt
# Label Values Legend
STRUCT: brain | cerebrum-{lh/rh} | corpus-callosum | cortex | {deep-gray|gray|white}-matter | ventricles 

When downloaded, the symlink files present within the M-CRIB-S derivatives (mcribs-0f306a2f/), appended with *_symlink_s3_object, appear as text files that contain the S3 object path instead of the actual file content. If needed, you may restore these files as symlinks via the following terminal command, which restores all symlink files within your locally downloaded directory and renames them without *_symlink_s3_object to match the original sourcedata filenames:

find . -type f -name "*_symlink_s3_object" -print | while read path ; do
  symval=$(cat "$path")
  symdir=$(dirname "$path")
  symbase=$(basename "$path" _symlink_s3_object)
  ln -s "$symval" "$symdir/$symbase" && rm -f "$path" || break

XCP-DπŸ”—

XCP-D performs functional MRI post-processing and noise regression from Infant-fMRIPrep derivatives, producing cleaned and parcellated data (see parcellation atlases) ready for analysis.

Anatomical Processing
Native-space T2w images are transformed into standard MNI152NLin6Asym space (1 mmΒ³ resolution). Morphometric surfaces (fsLR-space) from Infant fMRIPrep are copied to the XCP-D derivatives. HCP-style midthickness, inflated, and very-inflated surfaces are generated from the white-matter and pial surface meshes and mapped to fsLR space.

Functional Processing
For each BOLD run, XCP-D performs a series of cleanup and quality-control steps:

  • First 4 volumes (dummy scans) are removed.
  • Motion correction: Framewise displacement (FD) is calculated per Power et al. (2014); volumes with FD > 0.3 mm flagged as high-motion outliers.
  • Nuisance regression: 36 confound regressors (motion, tissue, and global signals plus derivatives) regressed out following the 36P strategy.
  • Despiking and filtering: Data despiked, temporally filtered (0.01–0.08 Hz), and smoothed (6 mm FWHM).
  • Censoring: High-motion volumes are interpolated and later censored to minimize motion artifacts.
  • Amplitude of Low-Frequency Fluctuations (ALFF) and Regional Homogeneity (ReHo) metrics computed from cleaned data.
  • Parcellated time series are extracted for each atlas and pairwise functional connectivity is calculated as the Pearson correlation between regional time series.
  • Postprocessed derivatives are concatenated across runs.
# JSON files excluded for brevity
 How To Read File Trees β†’

hbcd/
└── derivatives/
    └── xcp_d-{HASH}/
        └── sub-[ID]/
            └── ses-[V0X]/
                β”œβ”€β”€ anat/
                β”‚   β”‚ # File Prefix: sub-[ID]_ses-[V0X]_hash-{HASH}_run-[X]
                β”‚   β”œβ”€β”€ *_space-MNI152NLin6Asym_desc-preproc_T2w.nii.gz    # Preprocessed T2w in MNI standard space
                β”‚   β”œβ”€β”€ *_hemi-{L|R}_space-fsLR_den-32k_{SURF}.surf.gii    # fsLR 32k cortical surfaces (L/R)
                β”‚   β”œβ”€β”€ *_space-fsLR_den-91k_{METRIC}.dscalar.nii          # Dense scalar maps (fsLR 91k grayordinates)
                β”‚   └── *_space-fsLR_seg-{PARC}_stat-mean_desc-{METRIC}_morph.tsv    # Atlas-based summary statistics
                β”‚
                β”œβ”€β”€ func/
                β”‚   β”‚ # Run-specific files ('run-[X]') are omitted for brevity if concatenated files are present
                β”‚   β”‚ # File Prefix: sub-[ID]_ses-[V0X]_hash-{HASH}_task-rest
                β”‚   β”‚
                β”‚   # Primary denoised BOLD outputs in fsLR grayordinate space + confound files
                β”‚   β”œβ”€β”€ *_space-fsLR_den-91k_desc-{denoised|denoisedSmoothed}_bold.dtseries.nii
                β”‚   β”œβ”€β”€ *_{motion|outliers}.tsv
                β”‚   β”œβ”€β”€ *_dir-PA_run-[X]_design.tsv
                β”‚
                β”‚   # Dense scalar maps
                β”‚   β”œβ”€β”€ *_dir-PA_run-[X]_space-fsLR_den-91k_stat-alff_desc-smooth_boldmap.dscalar.nii
                β”‚   β”œβ”€β”€ *_dir-PA_run-[X]_space-fsLR_den-91k_stat-{alff|reho}_boldmap.dscalar.nii
                β”‚
                β”‚   # Parcellated outputs
                β”‚   β”œβ”€β”€ *_space-fsLR_seg-{PARC}_den-91k_stat-mean_timeseries.ptseries.nii
                β”‚   β”œβ”€β”€ *_space-fsLR_seg-{PARC}_stat-mean_timeseries.tsv
                β”‚   β”œβ”€β”€ *_space-fsLR_seg-{PARC}_stat-pearsoncorrelation_relmat.tsv
                β”‚   β”œβ”€β”€ *_dir-PA_run-[X]_space-fsLR_seg-{PARC}_den-91k_stat-pearsoncorrelation_boldmap.pconn.nii
                β”‚   β”œβ”€β”€ *_dir-PA_run-[X]_space-fsLR_seg-{PARC}_den-91k_stat-coverage_boldmap.pscalar.nii
                β”‚   β”œβ”€β”€ *_dir-PA_run-[X]_space-fsLR_seg-{PARC}_stat-coverage_bold.tsv
                β”‚   β”œβ”€β”€ *_dir-PA_run-[X]_space-fsLR_seg-{PARC}_stat-{alff|reho}_bold.tsv
                β”‚
                β”‚   # Quality control metrics
                β”‚   β”œβ”€β”€ *_dir-PA_run-[X]_space-fsLR_den-91k_desc-linc_qc.tsv
                β”‚   └── *_desc-abcc_qc.hdf5
                β”‚
                β”œβ”€β”€ figures/*
                β”œβ”€β”€ sub-[ID]_ses-[V0X]_hash-{HASH}_executive_summary.html
                └── sub-[ID].html

# ── Label Legend ─────────────────────────────────────────────
HASH    : 0f306a2f+0ef9c88a , 2afa9081+0ef9c88a
METRIC  : curv , sulc , thickness  
PARC    : 4S-{156|256|...|1056}Parcels , Glasser , Gordon , MIDB , MyersLabonte , HCP (func/ only) , Tian  (func/ only)
SURF    : midthickness , pial , white , inflated , vinflated

QC Pipelines: MRIQC & BME-XπŸ”—

MRIQC extracts image quality metrics (IQMs) for each T1w/T2w and functional BOLD run and generates visual .html reports. The BME-X pipeline performs motion correction, resolution enhancement, denoising, and harmonization of MR images.

hbcd/
└── derivatives/
    β”œβ”€β”€ mriqc/                            
    β”‚   β”œβ”€β”€ sub-[ID]/
    β”‚   β”‚   └── ses-[V0X]/
    β”‚   β”‚       β”œβ”€β”€ anat/
    β”‚   β”‚       β”‚   └── sub-[ID]_ses-[V0X]_run-[X]_{T1w|T2w}.json
    β”‚   β”‚       └── func/
    β”‚   β”‚           └── sub-[ID]_ses-[V0X]_run-[X]_{T1w|T2w}.json
    β”‚   └── sub-[ID]_ses-[V0X]_run-[X]_{T1w|T2w}.html
    β”‚
    └── bme-x/                  
        └── sub-[ID]/
            └── ses-[V0X]/
                └── anat/
                    |__ sub-[ID]_ses-[V0X]_run-[X]_desc-{enhanced|preproc}_{T1w|T2w}.nii.gz (+JSON)
                    |__ sub-[ID]_ses-[V0X]_run-[X]_space-{T1w|T2w}_desc-brain_mask.nii.gz (+JSON)
                    |__ sub-[ID]_ses-[V0X]_run-[X]_{T1w|T2w}.nii.gz (+JSON)

 How To Read File Trees β†’

MRI Derivatives Quick Start GuideπŸ”—

Below is a summary of key MRI derivatives used for structural morphology and resting-state functional MRI (rsfMRI) functional connectivity analyses. Key derivatives, produced by the XCP-D pipeline, include volumetric and surface-based time series for each participant. The data release also includes dense and parcellated time series with at least 2.5 minutes of low-motion data (FD>0.3), functional connectivity matrices, regional homogeneity values, and amplitude of low-frequency fluctuation values.

Curvature, Sulcal Depth, & Cortical Thickness

These CIFTI scalar files contain surface-based structural metrics derived from reconstructed L/R cortical surfaces, aligned to the fsLR template (~64k vertices per hemisphere).

  • Curvature: Characterizes cortical folding and morphology; often used as a covariate in morphometric analyses.
  • Sulcal depth: Complements curvature to describe cortical shape and folding complexity.
  • Cortical thickness: Distance between pial and white matter surfaces (mm); typically averaged within ROIs or compared across participants to study development, aging, or group effects.

Parcellated Structural Measures

Tabulated summaries of cortical metrics (curvature, sulcal depth, thickness) within anatomical regions defined by parcellation atlases. These files provide regional averages for statistical modeling or visualization.

Midthickness, Pial, and White Matter Surfaces

3D surface models representing the midthickness, gray–white matter boundary, and pial surfaces for each hemisphere. Useful for rendering structural data, computing surface-based metrics, or visualizing functional overlays.

Dense Timeseries

CIFTI dense time series containing fully preprocessed, temporally filtered, and nuisance-regressed BOLD data. These files combine the left and right surfaces, aligned to the standard fsLR surface template, with the subcortical volume annotated by subcortical structure. Each greyordinate (~96k total) represents a vertex or voxel with pre-processed resting-state functional MRI time-series.

Parcellated Timeseries

Tabulated mean BOLD time series for each region in the parcellation atlases. Also available as CIFTI .ptseries.nii files, where columns = regions and rows = timepoints.

Connectivity Matrices

Tab-delimited matrices of pairwise Pearson correlations between atlas regions, computed from parcellated time series using all available low-motion data (motion censored with a framewise displacement threshold of 0.3 mm). These matrices form the foundation for ROI-to-ROI connectivity analyses.

Motion Detection and Confound Files

Includes framewise displacement values and nuisance regressor design files. Design files contain one column per regressor (e.g., motion parameters, high-motion outlier volume indicators). See the XCP-D documentation for details.

See Parcellations & Atlases in the XCP-D documentation for more details.

Atlas Description
Glasser Multimodal anatomical atlas (population-level) Derived from multimodal MRI data (Glasser et al., 2016) Surface-based morphology, population-level structure
Gordon Functional atlas (333 ROIs) rs-fMRI boundary detection (120 young adults, ~14 min per subject; Gordon et al., 2016) Functional network mapping, group-level FC analyses
HCP Multimodal cortical atlas (360 ROIs) Combined task, resting-state, and diffusion MRI (210 young adults; Glasser et al., 2013) Cross-modal structural–functional alignment
MIDB Precision functional atlas (individualized) Derived from ABCD data using a 75% probability threshold (Hermosillo et al., 2024) Individualized functional network mapping
Myers-Labonte Infant probabilistic functional atlas 50% probability threshold; infant population (Myers et al., 2023) Infant functional network mapping
Tian Subcortical parcellation atlas High-resolution subcortical segmentation (Tian et al., 2020) Subcortical connectivity analyses
4S{X}56Parcels Multimodal atlas (multi-resolution) Schaefer cortical parcellations (100–1000 parcels) supplemented with subcortical and cerebellar regions (AtlasPack) Cross-modality alignment across XCP-D, QSIPrep, and ASLPrep

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