Page Last Updated: May 13, 2026

ASSIST V1-V4🔗

Alcohol, Smoking and Substance Involvement Screening Test V1-V4

Table Namepex_bm_assist{v1|v2|v3|v4}
Construct ASSIST substance use assessment across visits:
  • V1: Pre-pregnancy and during pregnancy
  • V2: Late pregnancy and early postnatal (0–4 weeks)
  • V3: Postpartum (3-month anchor)
  • V4: Postpartum (12-month anchor)
VisitsV01, V02, V03, V04
Administration Child-specific: No
Respondent: Pregnant Participant/Birth Parent (as applicable)
Method: Staff-administered, in-person (self-administered in Alabama) (3-5 min estimated duration)
Quality Control Response distributions are reviewed for outliers. For V1-V2, responses are cross-checked with TLFB for consistency in reported substance use.
Responsible Use Warning: V1 & V2 ▸

Responsible use of prenatal drug exposure data requires thoughtful interpretation of exposure-related outcomes in the context of measured and unmeasured confounders. These confounders include, but are not limited to, phenotypic risks associated with persistent alcohol, tobacco, and other drug use during pregnancy by birthing parents (Massey et al., 2010), and confounding by familial risk from within-family studies (Estabrook et al., 2016).

Finally, unwarranted speculation about ‘neural bases of behavior’ form differences in neuroimaging between exposed and unexposed children in the absence of differences in behavioral performance can exacerbate stigma already faced by birthing parents with substance use disorders and their children (McAllister & Hart 2015).

Data Warning ▸

It was difficult for some participants to self-report the typical size of a single drink (in oz) to capture ‘standard drinks’ of alcohol for ASSIST, leading to some reports falling outside the expected range. Similarly, reporting the frequency of use for substances like electronic cigarette devices proved difficult, resulting in outliers. While sites were queried on these outliers, participants could not always be re-contacted for clarification.

Please review the Known Issues & Pending Updates page for updates that may affect data use.

Instrument Details🔗

The HBCD ASSIST measures were modified from the NIDA Quick Screen (Modified ASSIST) and included questions from the Family History Assessment Module (FHAM) and the All of Us Personal and Family Health History. The original NIDA quick screen was scored; however, our version is not scored. To acknowledge these changes in future publications, authors can note that questions were motivated from the NIDA Modified ASSIST.

The NIDA quick screen tool (have you used alcohol, tobacco, prescription drugs, or illegal drugs in the last year) was modified to assess more details regarding types of substances used and the timeline of use before and during pregnancy - see HBCD Modification Details for modifications made to each instrument version. In addition, for lifetime and problematic use, and use pre-pregnancy, pregnancy, end-pregnancy, post-pregnancy, and past 3 months, use was greatly expanded - see Expanded ASSIST Substance Type Options.

Finally, the Time Line Follow Back (TLFB) was triggered when substance use was reported before [pre-use] or during pregnancy [during_use] on the ASSIST V1 or at the end of pregnancy [end_use] on the ASSIST V2 (see documentation on TLFB).

HBCD Modification Details ▸

Replacement Questions for NIDA Quick Screen Tool

    ASSIST V1
    Assess lifetime use [lt] and disordered use, or use causing problems in their lives:
    • [lt_use] IN YOUR LIFE, which of the following substances have you EVER used for any reason? [followed by list of substance options from section below]
    • [concern] Have you EVER been concerned about your use of this substance or worried it was problematic use?
    • [concernoth] Has a friend, relative, or anyone else EVER expressed concern about your use of this substance?
    • [control] Have you EVER tried and failed to control, cut down, or stop using this substance?
    • [tx] Have you EVER sought or received treatment related to your use of this substance by a medical provider, spiritual leader, community mutual help group (like AA or SMART Recovery), counselors, or in other settings
    • [diagn] Have you EVER been clinically diagnosed with abuse, dependence, or a substance use disorder related to your use of this substance
    • [med] Have you EVER taken (prescribed or otherwise) medication(s) as treatment for a problem substance
    Assess use 3 months pre-pregnancy [pre] and use during pregnancy [during]:
    • [pre_use] IN THE THREE MONTHS BEFORE YOU BECAME PREGNANT, which of the following substances have you ever used for any reason? [followed by list of substance options from section below]
    • [during_use] DURING YOUR PREGNANCY, which of the following substances have you ever used for any reason? [followed by list of substance options from section below]
    • [during_med] DURING YOUR PREGNANCY, did you take (prescribed or otherwise) medication(s) as treatment for a problem substance? [followed by list of medications used to treat substance use problems]
    ASSIST V2
    Assess use after pregnancy:
    • [end_use] SINCE WE LAST MET UNTIL THE END OF PREGNANCY, which of the following substances did you use for any reason? [followed by list of substance options from section below]
    • [end_med] SINCE WE LAST MET UNTIL THE END OF PREGNANCY, did you take (prescribed or otherwise) medication(s) as treatment for a problem substance? [followed by list of medications used to treat substance use problems]
    • [post_use] FROM THE TIME THAT YOU DELIVERED your child until now, how often have you used any of the following substances for any reason? [followed by list of substance options from section below]
    ASSIST V3
    Assess use and impact of substance use after pregnancy in past 3 months (3m):
    • [3m_use] IN THE PAST THREE MONTHS, how often have you used any of the following substances for any reason? [followed by list of substance options from section below]
    • [problem] DURING THE PAST THREE MONTHS, has your use of this substance led to physical or mental health, social, or financial problems?
    • [perform] DURING THE PAST THREE MONTHS, have you ever failed to do what was normally expected of you (like work, go to school, be a parent, or household tasks) because of your use of this substance?
    ASSIST V4
    Assess use and impact of substance use after pregnancy in past 12 months (12m):
    • [12m_use] IN THE PAST TWELVE MONTHS, how often have you used any of the following substances for any reason? [followed by list of substance options from section below]
    • [problem] DURING THE PAST TWELVE MONTHS, has your use of this substance led to physical or mental health, social, or financial problems?
    • [perform] DURING THE PAST TWELVE MONTHS, have you ever failed to do what was normally expected of you (like work, go to school, be a parent, or household tasks) because of your use of this substance?
Expanded ASSIST Substance Type Options ▸
  • [001] Nicotine or tobacco products (cigarettes, e-cigarettes, chewing tobacco, cigars, etc.)
  • [002] Alcoholic beverages (beer, wine, spirits, etc.)
    • IF ENDORSED: specify type and average volume of one glass/container typically consumed (U.S.-defined ‘standard drinks’ were then calculated by dividing the amount reported by 12oz (beer, hard cider, hard seltzer), 5oz (wine) or 1.5 oz (spirits))
  • [003] Cannabis (marijuana, weed, pot, hash, wax, blunts, dabs, gummies, vapes, etc.)
  • [004] Cannabidiol (CBD; not containing THC)
  • [005] Synthetic cannabinoids (K2, spice, etc.)
  • [006] Prescription opioids (oxycodone, morphine, codeine, fentanyl, tramadol, etc.)
    • IF ENDORSED: specify type of opioid used and typical quantities per occasion for the following: heroin (grams, bags), prescription opioids (pills), buprenorphine (pills, injectables, films), and methadone (mg)
  • [007] Heroin or other illicit opioids (fentanyl, oxycodone, etc.)
  • [008] Methadone
  • [009] Buprenorphine
  • [010] Benzodiazepines, sedatives, or sleeping pills (Valium, Xanax, Ambien, barbiturates, etc.)
  • [011] Cocaine (coke, crack, etc.)
  • [012] Amphetamine type stimulants (speed, Adderall, diet pills, etc.)
  • [013] Methamphetamine (meth, crystal meth, etc.)
  • [014] Inhalants (nitrous, glue, petrol, paint thinner, etc.)
  • [015] Hallucinogens or club drugs (LSD, acid, mushrooms, psilocybin, MDMA, molly, ecstasy, Special K, GHB, etc.)
  • [016] Androgenic anabolic steroids (for performance enhancement)
  • [017] Phencyclidine (PCP)
  • [018] Kratom
  • [019] Xylazine
    • Medications used to treat substance use problems
  • [001] Acamprosate (Campral), topiramate (Topamax), or gabapentin (Neurontin)
  • [002] Disulfiram (Antabuse)
  • [003] Naltrexone (Revia, Vivitrol)
Scoring Procedures ▸

For each substance, participants indicate whether they had ever used it and, if endorsed, frequency of use with options: 0 (Never), 1 (Once or Twice), 2 (Monthly), 3 (Weekly), or 4 (Daily or Almost Daily). For substances reported as used pre-pregnancy, during pregnancy, and end-pregnancy, participants were asked about modes of use and typical quantities/amounts of consumption for alcohol and opioids (if applicable).

References🔗

Coles, C. D. (1993). Saying “goodbye” to the “crack baby.” Neurotoxicology and Teratology, 15(5), 290–292; discussion 311-2. https://doi.org/10.1016/0892-0362(93)90024-i

Estabrook, R., Massey, S. H., Clark, C. A. C., Burns, J. L., Mustanski, B. S., Cook, E. H., O’Brien, T. C., Makowski, B., Espy, K. A., & Wakschlag, L. S. (2016). Separating family-level and direct exposure effects of smoking during pregnancy on offspring externalizing symptoms: Bridging the behavior genetic and behavior teratologic divide. Behavior Genetics, 46(3), 389–402. https://doi.org/10.1007/s10519-015-9762-2

Gal, P., & Sharpless, M. K. (1984). Fetal drug exposure-behavioral teratogenesis. Drug Intelligence & Clinical Pharmacy, 18(3), 186–201. https://doi.org/10.1177/106002808401800304

Level, R. A., Zhang, Y., Tiemeier, H., Estabrook, R., Shaw, D. S., Leve, L. D., Wakschlag, L. S., Reiss, D., Neiderhiser, J. M., & Massey, S. H. (2024). Unique influences of pregnancy and anticipated parenting on cigarette smoking: results and implications of a within-person, between-pregnancy study. Archives of Women’s Mental Health, 27(2), 301–308. https://doi.org/10.1007/s00737-023-01396-z

Massey, S. H., Lieberman, D. Z., Reiss, D., Leve, L. D., Shaw, D. S., & Neiderhiser, J. M. (2010). Association of clinical characteristics and cessation of tobacco, alcohol, and illicit drug use during pregnancy. The American Journal on Addictions, no-no. https://doi.org/10.1111/j.1521-0391.2010.00110.x

McAllister, D., & Hart, C. L. (2015). Inappropriate interpretations of prenatal drug use data can be worse than the drugs themselves. Neurotoxicology and Teratology, 52, 57. https://doi.org/10.1016/j.ntt.2015.07.002

National Institute on Drug Abuse. (n.d.). NIDA Modified ASSIST.

Shah, S. K., Perez-Cardona, L., Helner, K., Massey, S. H., Premkumar, A., Edwards, R., Norton, E. S., Rogers, C. E., Miller, E. S., Smyser, C. D., Davis, M. M., & Wakschlag, L. S. (2023). How penalizing substance use in pregnancy affects treatment and research: a qualitative examination of researchers’ perspectives. Journal of Law and the Biosciences, 10(2), lsad019. https://doi.org/10.1093/jlb/lsad019

Wakeman, S. E., Bryant, A., & Harrison, N. (2022). Redefining child protection. Obstetrics and Gynecology, 140(2), 167–173. https://doi.org/10.1097/aog.0000000000004786