Page Last Updated: June 20, 2026

HBCD Study Protocol Overview🔗

Age of Child participants at each Visit number: Visit 1 (V01) = Prenatal; Visit 2 (V02) = 0-1 month old; Visit 3 (V03) = 3-9 months old; Visit 4 (V04) = 9-15 months old; Visit 5 (V05) = 10-17 months old; Visit 6 (V06) = 15-30 months old; Visit 7 (V07) = 16-32 months old

Participant Population🔗

HBCD enrolls at least 25% of participants with more than minimal substance use during pregnancy, including opioids (Si et al. 2024). Enrollment strategies aim to yield a study population representative of individual and geographic characteristics of pregnant and postpartum individuals (18 years or older) in the U.S., including an adequate comparison group for substance-exposed individuals (Nelson et al. 2024).

Spanish Translations🔗

All surveys used in the HBCD Study were translated into Spanish by BURG Translations and reviewed by the Spanish Language Committee (SLC) to ensure clarity and accessibility for a broad Spanish-speaking population. Instruments from third-party publishers (e.g., Bayley, CDI, BTB, Vineland) were excluded from this process, and the third party's translation was used.