File-Based Data🔗

File-based data is provided for imaging, EEG, and biosensor recordings. Unlike tabulated data (tables organized in a uniform way across study instruments), file-based data comes in a variety of formats, often modality-specific. File-based data includes:

• Raw BIDS: raw data converted to the BIDS standard with unaltered signal content
• Derivatives: processed datasets generated by standardized pipelines
• Concatenated Data: participant-level files aggregated across all subjects for select measures

Raw BIDS🔗

Raw BIDS are raw file-based data in BIDS format and include MRI, MRS, EEG, and wearable sensor recordings. Data are located under rawdata/ in subject, session, and modality-specific subfolders. Visit the following links to see full file contents and documentation for each modality:

hbcd/
└── rawdata/
    # Raw BIDS (MRI/MRS, EEG, biosensors)
    ├── sub-[ID]/
    │   └── ses-[V0X]/
    │       ├── anat/     # Imaging & Spectroscopy
    │       ├── dwi/
    │       ├── fmap/
    │       ├── func/
    │       ├── mrs/
    │       ├── eeg/      # EEG
    │       ├── motion/   # Wearable sensors
            └── sub-[ID]_ses-[V0X]_scans.tsv
    │
    # Dataset-level metadata
    ├── dataset_description.json
    └── participants.tsv
    ├── sub-[ID]_ses-[V0X]_scans.tsv

Participant-, Session-, & Scan-Level Data🔗

Participant-Level Data - participants.tsv
General participant information (e.g., sex) to provide high-level overview of all study participants

Session-Level Data - sub-[ID]_sessions.tsv
Session information, including collection site, age at session, and head size

Scan-Level Data - sub-[ID]_ses-[V0X]_scans.tsv
Per-scan information, including key fields of interest such as raw data QC metrics and scanner information

---

Derivatives🔗

The derivatives/ folder contains derivatives, which are file outputs from processing pipelines.

hbcd/
└── derivatives/
    # Structural & Functional MRI
    ├── mriqc/
    ├── bme_x/
    ├── bibsnet/
    ├── nibabies/
    ├── freesurfer/
    ├── mcribs/
    ├── xcp_d/

    # Quantitative MRI
    ├── symri/
    ├── qmri_postproc/

    # Diffusion MRI
    ├── qsiprep/
    ├── qsirecon/
    ├── qsirecon-DIPYDKI/
    ├── qsirecon-DSIStudio/
    ├── qsirecon-TORTOISE_model-MAPMRI/
    └── qsirecon-TORTOISE_model-tensor/

    # Other Modalities
    ├── osprey/       # MRS
    ├── made/         # EEG
    └── hbcd_motion/  # Biosensor Recordings

---

Concatenated Data🔗

Similar to tabulated data, concatenated data are participant-level datasets aggregated across all participants into a single file or file set. The key difference is that the data are not converted to the HBCD standard tabulated format. This is needed in cases where datasets include cohort-wide data and/or the original community-standard formats are required to support common analysis workflows and maximize compatibility with existing tools. Click View README links below to view instrument documentation.

hbcd/
└── concatenated/
    # Illumina Global Diversity GWAS Array - View README
    ├── genetics/
    │   └── genotype_microarray/
    │       └── GDA/
    │           ├── batch.info
    │           ├── hbcd.bed
    │           ├── hbcd.bim
    │           └── hbcd.fam
    │
    # Geocoded Linked External Data (GLED) - View README
    ├── geocoding/
    │   └── HBCD_address_history_geocoded.csv
    │
    # Olink Explore 384 Inflammation 1 Panel - View README
    ├── proteins/
    │   └── olink/
    │       └── inflammation/
    │           ├── Olink_allplates_long.csv
    │           └── Olink_allplates_wide.csv
    │
    # Study Navigator Contact Form - View README
    └── study_navigator/
        └── study_navigator_export.csv